When Does Deep Representation Learning Help Single-Cell Clustering? A Sensitivity-Aware Diagnostic Benchmark for Biomedical AI Pipelines

arXiv:2607.25288v1 Announce Type: new Abstract: Single-cell ribonucleic acid sequencing (scRNA-seq) is a foundational technology for precision-medicine workflows that contribute to United Nations Sustainable Development Goal 3 on Good Health and Well-being, and unsupervised clustering is the analytical step that turns raw expression matrices into interpretable cell populations. Practitioners therefore face a recurring engineering decision: is an additional deep representation stage worth its com...

arXiv cs.LG ·Nguyen Thanh Phong, Truong Viet Vu, Nguyen Ha Thu, Tran An Ky, Tran Hoang Thong, Le Pham Thuy Hien, Nguyen Thai Anh ·
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