DrugGen 2: A disease-aware language model for enhancing drug discovery

DrugGen 2: A disease-aware language model for enhancing drug discovery

DrugGen-2 generates small molecules conditioned on disease ontology and target protein sequences through fine-tuning GPT-2 with supervised learning and reinforcement learning using…

Hugging Face · Daily Papers ·Ali Motahharynia, Mohammadreza Ghaffarzadeh-Esfahani · ·▲ 1 upvotes

Este artigo está em destaque na seleção diária de papers do Hugging Face, curada pela comunidade de pesquisa em IA.

Autores: Ali Motahharynia, Mohammadreza Ghaffarzadeh-Esfahani, Mahsa Sheikholeslami, Navid Mazrouei, Matin Irajpour, Yousof Gheisari

  • 1 upvotes da comunidade
  • Temas: GPT-2, supervised fine-tuning, reinforcement learning, group relative policy optimization, chemical validity, molecular generation

Resumo

Resumo original (em inglês), extraído do paper:

DrugGen-2 generates small molecules conditioned on disease ontology and target protein sequences through fine-tuning GPT-2 with supervised learning and reinforcement learning using GRPO, achieving superior molecular diversity and binding affinity compared to baseline models.

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